melasma Synbiotics,
Conditions
Interventions
TS6 synbiotic oral supplementation
1 sachet/day,maltodextrin,
citric acid and orange flavor
1 sachet/day
Experimental Dietary Supplement,Placebo Comparator No treatment
TS6,placebo
Sponsors
Mae Fah Luang university
Mae Fah Luang university
Eligibility
Sex/Gender
Female
Age
30 Years to 50 Years
Inclusion criteria
Inclusion criteria: 3.4.1.1 Patients with melasma were recruited from local dermatology clinics or internet who presented bilateral epidermal or mixed melasma. 3.4.1.2 Female, age 30 to 50 years old with Fitzpatrick skin type’s III to type VI 3.4.1.3 All patients did not receive any other treatment for melasma for two months except for sunscreen. 3.4.1.4 All subjects were willing to be involved in the treatment 28 days for 3 consecutive visits. 3.4.1.5 All subjects were willing to abstain from any facial procedure during the study. 3.4.1.6 All subjects were willing to abstain from other oral supplementation during the study. 3.4.1.7 All females of reproductive age agreed to use birth control during the study.
Exclusion criteria
Exclusion criteria: 3.4.2.1 Pregnant women 3.4.2.2 Women who were breastfeeding 3.4.2.3 Subjects with personal medication such as oral contraceptives, spironolactone or phenytoin 3.4.2.4 Being treated with tretinoin through the last three weeks 3.4.2.5 Being treated with hydroquinone through the last six months 3.4.2.6 Cow milk hypersensitivity reactions 3.4.2.7 Drug or alcohol Consumption. 3.4.2.8 Medical illness such as poorly controlled diabetic mellitus, coagulopathy, photosensivity and immunosuppressant 3.4.2.9 History of strong UV exposure in some career or leisure activity (confounder) 3.4.2.10 Individuals with other strong confounder including those with regularly use cosmetics or consume food that adversely affects the skin’s condition, those with skin abnormality/disease that requires treatment, those who excessively consume alcohol, current smokers (smoking over 20 cigarettes/day) and those judged inappropriate for this study based on subject background, physical findings or medical examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| severity of melasma At the beginning of the study, day29, day57 and day 85 Modified MASI score | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin Health At the beginning of the study, day29, day57 and day 85 skin pigmentation, skin elasticity, TEWL | — |
Countries
thailand
Contacts
Public ContactPiyanat Piyavatin
Mae Fah Luang Universityy
Outcome results
None listed