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Efficacy and safety of a hair growth promoting product containing topical 1% melatonin for treatment of androgenetic alopecia in women: A randomized double-blind trial

Efficacy and safety of a hair growth promoting product containing topical 1% melatonin for treatment of androgenetic alopecia in women: A randomized double-blind trial

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20201227001
Enrollment
100
Registered
2020-12-27
Start date
2020-10-15
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female pattern hair loss (Androgenetic alopecia)

Interventions

5% Minoxidil solution with 1% Melatonin solution,1% Melatonin solution ,5% Minoxidil solution,Placebo
Experimental Drug,Experimental Drug,Active Comparator Drug,Placebo Comparator Drug
Combination group,Melatonin group,Minoxidil group,Placebo group

Sponsors

Faculty of Medicine, Thammasat University (Rungsit campus)
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Female pattern hair loss (Androgenetic alopecia), Type II - V of Sinclair scale 2. Healthy status

Exclusion criteria

Exclusion criteria: 1. No topical treatment include minoxidil for AGA within 6 months 2. No topical herb solution for hair growth within 6 months 3. No systemic treatment for AGA within 6 months. For example, oral contraceptive drug, finasteride, dutasteride, spironolactone 4. No history of chemotherapy and radiation within 1 year prior to the clinical trials 5. No topical steroid that apply a scalp at least 14 days within 3 months prior to the trials 6. No pregnancy and breastfeeding status 7. No history of hypersensitivity to melatonin and minoxidil 8. No multiple comorbidities

Design outcomes

Primary

MeasureTime frame
Target area hair counts 0,2,4,6 months Leviacam (Trichoscopy)

Secondary

MeasureTime frame
Comb-and-Count 0,2,4,6 months number,Global assessment by photo 0,2,4,6 months 7 scales

Countries

Thailand

Contacts

Public ContactPanlop Chakkavittumrong

Faculty of Medicine

panlop078@gmail.com6690-989-4056

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026