Minimum effective volume of crystalloid to prevent spinal induced hypotension during elective cesarean delivery: An up-down sequential allocation design

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20201223006

Enrollment

100

Registered

2020-12-23

Start date

2020-12-25

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy pregnancy patients Pregnancy Coload spinal anesthesia hypotension

Interventions

Intravenous co&#45

loading is one of the strategy to prevent hypotension after spinal anesthesia. This study aim to find the effective volume of co&#45

loading to prevent spinal anesthesia. we use up&#45

down sequential approach to find the effective volume start at 500 ml and if the patient developed spinal hypotension. The next volume will be inclemently increase 1 ml/kg. On the other hand&#44

if patient doesn&#39

t have hypotension. The next volume will be decrease 1 ml/kg.

Experimental Drug

Intravenous coload

Eligibility

Sex/Gender

Female

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Singleton term pregnancy Elective cesarean delivery American Society of Anesthesiology classification I-II

Exclusion criteria

Exclusion criteria: History of hypertensive disorder Gestational age less than 37 weeks History of cardiovascular disease History of morbid obesity (Pre-pregnancy BMI > 35 kg/m2) Height less than 150 cm or more than 190 cm Inadequate or failed spinal anesthesia High or total spinal anesthesia

Design outcomes

Primary

Measure	Time frame
volume of crystalloid to prevent spinal hypotension every 2.5 minute until 20 minute after spinal anesthesia milliliter of crystalloid co-loading at time of spinal anesthesia	—

Secondary

Measure	Time frame
Cardiac output before, after spinal anesthesia every 2.5 min until 20 minute after spinal block bioimpedance cardiac output measurement,Vassopressor usage end of surgery Total dose of vassopressor after surgery,Baby outcomes after baby delivery 1 and 5 minute apgar score, umbilical artery and venous cord blood gases	—

Countries

Thailand

Contacts

Public Contactlisa sangkum

Ramathibodi hospital

lisa.sangkum@gmail.com+66989075899

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Minimum effective volume of crystalloid to prevent spinal induced hypotension during elective cesarean delivery: An up&#45;down sequential allocation design