transient ischemic attack Ischemic stroke Brain Supplement Mulberry transient ischemic attack Ischemic stroke
Conditions
Interventions
Subjects are received the placebo product which has same color and smell look like product of Mulberry capsule ,Subjects are received product of Mulberry capsule 1000 mg/day,Subjects are received prod
medication plus placebo,medication plus Mulberry capsule 1000 mg/day,medication plus Mulberry capsule 2000 mg/day
Sponsors
Health Systems Research Institute, Thailand (HSRI)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Acute ischaemic stroke within the past 5-10 days that caused hemiparesis or hemiplegia 2. Aged between 18 years and 70 years 3. Fugl-Meyer motor scale (FMMS) scores of 55 or less at baseline
Exclusion criteria
Exclusion criteria: 1. Post rt-PA 2. Severe post-stroke disability (NIHSS score >20) 3. Previous stroke with motor deficit, comprehension deficits (aphasia) 4. Previous depression or MADRS score of more than 19; taking antidepressant drugs, monoamine oxidase inhibitors, neuroleptic drugs, or benzodiazepines during the month before inclusion 5. Undergoing carotid endarterectomy 6. Pregnancy 7. Major diseases that would prevent follow-up. Enrolment, follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The changes of hematological and clinical chemistry parameters 6 weeks laboratory | — |
Secondary
| Measure | Time frame |
|---|---|
| vascular cell adhesion molecule1(VCAM-1) 6 weeks ELISA Kit ,Matrix metalloproteinases 9 (MMP-9) 6 weeks ELISA Kit ,VonWillebrand Factor (VWF) 6 weeks ELISA Kit ,S100β 6 weeks ELISA Kit ,Safety evaluation and side effect 6 weeks Questionair,Electrocardiogram 6 weeks electrocardiography equipment,NIHSS score 6 weeks Questionair,Stool examination (PH, Lactobacillus spp., Bifidobacterium spp. and Short chain fatty acid) 6 weeks laboratory | — |
Countries
Thailand
Contacts
Public ContactSupaporn Muchimapura
Khon Kaen University
Outcome results
None listed