Effect of cashew nut protein hydrolysate plus fiber on changes of cognitive function in middle age and elderly volunteers

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20201222004

Enrollment

Registered

2020-12-22

Start date

2021-04-19

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy conditions Cashew nut Protein hydrolysate Cognitive function Middle age Elderly

Interventions

Subjects are received the placebo product which has same color and smell look like encapsulated cashew derived protein hydrolysate plus fiber,Subjects are received encapsulated cashew nut protein hydr

200 mg/day

Placebo Comparator Dietary Supplement,Experimental Dietary Supplement,Experimental Dietary Supplement

Placebo,Encapsulated cashew nut protein hydrolysate plus fiber 600 mg/day,Encapsulated cashew nut protein hydrolysate plus fiber 1&#44

Eligibility

Sex/Gender

All

Age

45 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 45-70 years old 2. Body Mass Index (BMI) 18.5-25 kg/m2

Exclusion criteria

Exclusion criteria: 1.Volunteers who have serious physical illness such as cardiovascular diseases, respiratory diseases, neuropsychological diseases, head injury, diabetes mellitus, liver disease, cancer, autoimmune diseases and hematological disorder 2.Volunteers who have been Hysterectomy and/or Oophorectomy 3.Volunteers who require supplements or any drug that effect on hypothalamic pituitary gonadal axis 4.Volunteers who require supplements or any drug that effect on the nervous system by order of the doctor during trial 5.Volunteers who have a regular exercise more than 3 times/week 6.Smoking more than 10 pieces/day 7.Alcohol addiction 8.Volunteers who participate in other projects.

Design outcomes

Primary

Measure	Time frame
N100 and P300 8 weeks Event related evoked potentials (ERPs)	—

Secondary

Measure	Time frame
Working memory test 8 weeks Computer,Acetylcholinesterase and Monoamine oxidase enzyme (MAOA and MAOB) 8 weeks Elisa method,The changes of Aging Marker (Telomere length) 8 weeks laboratory,Inflammatory markers include IL-6 and TNF-Î± 8 weeks Elisa method,Immune markers include CD4, CD8 and CD28 8 weeks Elisa method,The changes of hematological and clinical chemistry parameters 8 weeks laboratory,The changes of beta-galactosidase enzyme 8 weeks Elisa method,The changes of atherosclerosis marker (homocysteine) 8 weeks laboratory,Metabolic parameters include HOMA-IR index, atherosclerosis index and oxidized LDL 8 weeks laboratory,Mood evaluation using Bond-ladder questionnaire 8 weeks Questionnaire,Psychological symptom using SCL-90 questionnaire 8 weeks Questionnaire,Anxiety, depression and insomnia evaluation using questionnaire 8 weeks Questionnaire,Stool examination (PH, Total lactic acid, Bifidobacterial, Short chain fatty acid) 8 weeks laboratory	—

Measure

Time frame

Working memory test 8 weeks Computer,Acetylcholinesterase and Monoamine oxidase enzyme (MAOA and MAOB) 8 weeks Elisa method,The changes of Aging Marker (Telomere length) 8 weeks laboratory,Inflammatory markers include IL-6 and TNF-Î± 8 weeks Elisa method,Immune markers include CD4, CD8 and CD28 8 weeks Elisa method,The changes of hematological and clinical chemistry parameters 8 weeks laboratory,The changes of beta-galactosidase enzyme 8 weeks Elisa method,The changes of atherosclerosis marker (homocysteine) 8 weeks laboratory,Metabolic parameters include HOMA-IR index, atherosclerosis index and oxidized LDL 8 weeks laboratory,Mood evaluation using Bond-ladder questionnaire 8 weeks Questionnaire,Psychological symptom using SCL-90 questionnaire 8 weeks Questionnaire,Anxiety, depression and insomnia evaluation using questionnaire 8 weeks Questionnaire,Stool examination (PH, Total lactic acid, Bifidobacterial, Short chain fatty acid) 8 weeks laboratory

—

Countries

Thailand

Contacts

Public ContactJintanaporn Wattanathorn

Khon Kaen University

jinwat@kku.ac.th6618721809

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026