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Efficacy of medium cut-off membrane hemodialysis on middle molecule uremic toxins reduction as comparable with mixed-dilution online HDF : Prospective cross-over study

Efficacy of medium cut-off membrane hemodialysis on middle molecule uremic toxins reduction as comparable with mixed-dilution online HDF : Prospective cross-over study

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20201219001
Enrollment
14
Registered
2020-12-19
Start date
2020-07-27
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

End stage renal disease Hemodialysis&#44

Interventions

medium cut&#45
off membrane hemodialysis using Theranova membrane ,mixed&#45
dilution online HDF
Experimental Procedure/Surgery,Experimental Procedure/Surgery
off membrane hemodialysis ,mixed&#45

Sponsors

The Kidney Foundation of Thailand
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1.Thai ESRD patient 18-90 year 2.Hemodialysis at KCMH 3/weeks 3.Hemodialysis 3/weeks with Kt/V >/= 1.2 4.Residual renal function /= 400 ml/min 6.Optimal dry weight 7.Hemodynamic stable at least 2 weeks before enrollment

Exclusion criteria

Exclusion criteria: 1.Severe infection 2.Severe CVD 3.Advanced stage malignancy 4.Advanced stage cirrhosis CTP B to C 5.Malnutrition 6.Pregnancy 7.Hemodynamic instability < 2 weeks before enrollment 8.Contraindication for anticoagulants 9.Deny informed consent

Design outcomes

Primary

MeasureTime frame
Rate of ß2&#45;microglobulin reduction 8 weeks percentage—

Secondary

MeasureTime frame
Rate of other middle molecules uremic toxin reduction 8 weeks percentage,Albumin loss in dialysate 8 weeks grams—

Countries

Thailand

Contacts

Public ContactJirarat Eiamcharoenying

King Chulalongkorn Memorial Hospital

jirarateiam@gmail.com086-511-5121

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026