Dyspepsia is a gastrointestinal disorder that is found in up to 20 percent of the world'
Conditions
Interventions
Patients received amitriptyline 10 mg daily plus omeprazole 20 mg daily for 8 weeks.,Patients received omeprazole 20 mg daily.
Experimental Drug,Active Comparator Drug
Low dose amitriptyline with PPIs,PPIs only
Sponsors
Nantikarn Yingrattanasuk
Roi Et Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients with functional dyspepsia as defined by Rome IV criteria who have not had an endoscopy (uninvestigated dyspepsia). 2. No history of taking the following drugs for at least 1 week: proton pump inhibitor, antacid, H2antagonist, prokinetic, antispasmodic, carminative.
Exclusion criteria
Exclusion criteria: 1. Have a history of hypersensitivity to Amitriptyline and / PPIs, or have a history of pregnancy or breastfeeding. 2. Have gastric malignancy, cardiac arrhythmia, congestive heart failure, untreated glaucoma, benign prostate hypertrophy, uncontrolled diabetes. 3. Have a history of using drug groups Antidepressant, Benzodiazepine, NSAIDs including fluoxetine, citalopram, fluvoxamine, sertraline, escitalopram, paroxetine, nortriptyline, mirtazapine, trazodon, chlordiazepoxide, clonazepam, clorazepate, clobazam, diazepam, flurazepam, lorazepam, midazolam, prazepam,triazolam, ibuprofen, naproxen, diclofenac, mefenamic acid, indomethacin and aspirin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Global overall symptom scale of dyspepsia 8 weeks self assessment | — |
Secondary
| Measure | Time frame |
|---|---|
| Global overall symptom scale of dyspepsia 8 weeks self assessment report | — |
Countries
Thailand
Contacts
Public ContactNantikarn Yingrattanasuk
Department of social medicine, Khon kaen hospital
Outcome results
None listed