Comparison of anesthetic effectiveness and safety of 2% lidocaine and 4% articaine for mandibular third molar impaction surgery â€“ A randomized control trial study

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20201218003

Enrollment

Unknown

Registered

2020-12-18

Start date

2020-07-01

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Duration of anesthesia Onset of anesthesia Cardiovascular change Visual analog scale Paresthesia Efficacy Articaine Lidocaine Mandibular third molar impaction Randomized Clinical

Interventions

2% lidocaine with epinephrine 1:100&#44

000 is sterile isotonic solutions containing a local anesthetic agent&#44

Lidocaine Hydrochloride&#44

and a vasoconstrictor&#44

Epinephrine (as bitartrate) and administered parenterally by injection. ,Articaine is an intermediate&#45

potency&#44

short&#45

acting amide local anesthetic with a fast metabolism due to an ester group in its structure. It proved to be suitable and safe for procedures requiring a short duration of action in which a fast onset

dental procedures in normal and in special populations.

Active Comparator Drug,Active Comparator Drug

2% Lidocaine,4% Articaine

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1.Patients with mesioangular positioned depth B lower third molar impaction 2.Absence of systemic illness(ASA I) 3.Age between 18 to 40 years old 4.Provided written informed consent 5.communicated with Thai language

Exclusion criteria

Exclusion criteria: 1.Patient has any signs of inflammation or infection at the extraction site 2.Pregnancy or current lactation 3.Take any other pain medication prior to the removal of third molar 4.History of allergic reaction of local anesthesia 5.History of bleeding tendency or was given any anticoagulant drugs

Design outcomes

Primary

Measure	Time frame
Duration of anesthesia at the beginning of placing the incision measured from time of placing the incision to the last suture placed,Onset of anesthesia at the beginning of injection recorded from time of injection of the onset of anesthesia of the lower lip,Cardiovascular change at the beginning of procedure recorded before procedure, during injection, placing the incision and sectioning of tooth ,Visual analog scale at the end of treatment Intra operatively pain was scored by patient,Paresthesia at the day of suture removal observed any signs of paresthesia clinically	—

Measure

Time frame

Duration of anesthesia at the beginning of placing the incision measured from time of placing the incision to the last suture placed,Onset of anesthesia at the beginning of injection recorded from time of injection of the onset of anesthesia of the lower lip,Cardiovascular change at the beginning of procedure recorded before procedure, during injection, placing the incision and sectioning of tooth ,Visual analog scale at the end of treatment Intra operatively pain was scored by patient,Paresthesia at the day of suture removal observed any signs of paresthesia clinically

—

Secondary

Measure	Time frame
N/A N/A N/A	—

Countries

Thailand

Contacts

Public ContactTarase Toemsukkasame

Charoenkrung Pracharak

oaktarase.t@gmail.com022897049

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026