Transabdominal hysterectomy is the most common gynecologic surgery. It also associates with moderate to severe postoperative pain. Multimodal analgesia is the best technique for pain control and impro dexamethasone,
Conditions
Interventions
Dexamethasone 10 mg intravenous before the operation for 1 hour. Nefopam 20 mg in normal saline solution 100 ml intravenous infusion in 30 minutes before the shin closure,
and continuous infusion 80 mg in normal saline solution 500 ml in 24 hours for the postoperative period.,Nefopam 20 mg in normal saline solution 100 ml intravenous infusion in 30 minutes before skin c
Dexamethasone with Nefopam group,Nefopam group,Dexamethasone group
Sponsors
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Eligibility
Sex/Gender
Female
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Female Age 20 -65 years old Undergoing TAH +/- BSO ASA physical status 1 or 2 Elective case
Exclusion criteria
Exclusion criteria: BMI > 35 kg/m2 Underlying disease: liver failure, renal failure, cardiac disease, psychiatric disorder Creatinine clearance < 30 ml/min History of seizure Chronic pain syndrome Allergy to Morphine, Dexamethasone, Nefopam, Parecoxib Inability to understand VNRS and/or control IV-PCA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total dose requirement of morphine via IVPCA in postoperative phase at 24 hour milligram | — |
Secondary
| Measure | Time frame |
|---|---|
| Verbal Numerical Rating Scale (VNRS) at 0, 1, 6, 12, 24 hour Numeric of pain score,adverse effects: nausea and vomiting, dyspepsia, hyperglycemia at 24 hour percentage | — |
Countries
Thailand
Contacts
Public ContactChusak Okascharoen
Ramathibodi Hospital, Mahidol University
Outcome results
None listed