The efficacy of topical recombinant human epidermal growth factor gel in combination with fractional radiofrequency microneedle in the treatment of mild to moderate atrophic acne scar

The efficacy of topical recombinant human epidermal growth factor gel in combination with fractional radiofrequency microneedle in the treatment of mild to moderate atrophic acne scar, A randomized split-face clinical study

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20201201003

Enrollment

Registered

2020-12-01

Start date

2020-11-03

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mild to moderate rolling and shallow boxcar acne scars

Interventions

Patients will have a treatment from fractional radiofrequency both side of face. and then apply topical EGF gel one side of face and another side apply placebo gel (split face),Patients will have a tr

Placebo Comparator Drug,Placebo Comparator Drug

Fractional radiofrequency with Topical EGF,Fractional radiofrequency with placebo gel

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1.mild to moderate rolling and shallow boxcar acne scars more than 6 months

Exclusion criteria

Exclusion criteria: 1.Use isotretanoin or Vitamin A derivative drugs within 6 months 2.Have a laser treatment for acne scars within 6 months 3.History of topical anesthesia allergy 4.Patient using cardiac pacemaker or defibrillator 5.Patient that skin prone to keloid easily

Design outcomes

Primary

Measure	Time frame
Improvement of acne scars after treatment with fractional radiofrequency and topical EGF in 3 months 3 months after treatment Investigator global assessment	—

Secondary

Measure	Time frame
changing of volume of acne scar after treatment in 3 months 3 months after treatment Antera3D camera,Dermal density after treatment in 3 months 3 months after treatment DermaLab skin ultrasound,Patient satisfaction after treatment with fractional radiofrequency and topical EGF 3 months after treatment Questionairs	—

Countries

Thailand

Contacts

Public ContactNalinee Pitipornchai

Unaffiliated

nalinee.pitipornchai@gmail.com0851012401

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026