Effects of Low Dose Fentanyl Supplementation of Reduced Dose Propofol during Electroconvulsive Therapy

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20201127005

Enrollment

Unknown

Registered

2020-11-27

Start date

2015-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

psychiatric patients who receiving electroconvulsive therapy Electroconvulsive therapy Fentanyl Hemodynamic response Propofol Thiopental Seizure duration

Interventions

receiving thiopental 2 mg/kg,receiving propofol 1 mg/kg,fentanyl 0.3 mcg/kg&#44

followed by propofol 0.5 mg/kg.

Active Comparator Drug,Active Comparator Drug,Experimental Drug

Thiopental group,Propofol group,Fentanyl plus propofol group

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: adults, aged 18-65 years old and scheduled for bilateral ECT treatment.

Exclusion criteria

Exclusion criteria: patients who had a history of cardiovascular or cerebrovascular disease, poorly controlled hypertension, pregnancy, obesity (body mass index > 30 kg/m2), and had a contraindication to use thiopental, propofol, fentanyl, or succinylcholine.

Design outcomes

Primary

Measure	Time frame
seizure duration Pre-dose, 1 min,2 min,3 min,4 min,5 min,6 min,7 min,8 min,9 min,10 min Post-dose EEG,blood pressure in,3 min,4 min,5 min,6 min,7 min,8 min,9 min,10 min Post-dose mmHg,blood pressure Pre-dose, 1,2,3,4,5,6,7,8,9,10 Post-dose mmHg,Oxygen satuaration in,3 min,4 min,5 min,6 min,7 min,8 min,9 min,10 min Post-dose pulse oxymeter ,heart rate in,3 min,4 min,5 min,6 min,7 min,8 min,9 min,10 min Post-dose EKG	—

Measure

Time frame

seizure duration Pre-dose, 1 min,2 min,3 min,4 min,5 min,6 min,7 min,8 min,9 min,10 min Post-dose EEG,blood pressure in,3 min,4 min,5 min,6 min,7 min,8 min,9 min,10 min Post-dose mmHg,blood pressure Pre-dose, 1,2,3,4,5,6,7,8,9,10 Post-dose mmHg,Oxygen satuaration in,3 min,4 min,5 min,6 min,7 min,8 min,9 min,10 min Post-dose pulse oxymeter ,heart rate in,3 min,4 min,5 min,6 min,7 min,8 min,9 min,10 min Post-dose EKG

—

Secondary

Measure	Time frame
BIS index in,3 min,4 min,5 min,6 min,7 min,8 min,9 min,10 min Post-dose BIS	—

Countries

Thailand

Contacts

Public ContactVarinee Lekprasert

Faculty of Medicine, Ramathibodi Hospital, Mahidol University

varinee.lek@mahidol.ac.th+66817212292

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026