Effect of sugar ingestion on forearm blood flow in male offspring of hypertensive parents

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20201127002

Enrollment

Registered

2020-11-27

Start date

2020-06-29

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Normotensive offspring of hypertensive parents Sugar Postprandial hyperglycemia Forearm blood flow Hypertension Oxidative stress

Interventions

Water 200 mL,15 grams of sugar (total volume of solution 200 mL),30 grams of sugar (total volume of solution 200 mL),60 grams of sugar (total volume of solution 200 mL)

Placebo Comparator Other,Experimental Other,Experimental Other,Experimental Other

Water ,Sugar 15 grams,Sugar 30 grams,Sugar 60 grams

Eligibility

Sex/Gender

Male

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1.Men whose age between 18-35 years 2.Healthy: normal blood pressure, normal fasting blood sugar, normal blood lipid levels and normal resting cardiac electrical signals 3.Sedentary lifestyle: physical activity of moderate intensity < 30 min/times, < 3 times/week for at least 3 months 4.BMI < 25 kg/m2 5.Farther and/or mother having high blood pressure records (the diagnosis made before 55 for father and 65 for mother) or currently on antihypertensive medicine for OHT group 6.Farther and/or mother having normal blood pressure records for ONT group 7.Without family history of diabetic

Exclusion criteria

Exclusion criteria: 1.Abnormalities in nerve and upper limb muscles 2.An open wound or muscle inflammation in arm and forearm area 3.Use medications for cardiovascular disease (include beta-blockers) 4.Use medications for decreased blood sugar

Design outcomes

Primary

Measure	Time frame
Peak forearm blood flow (FBF) before and every 30 minutes after sugar ingestion for a period of 2 hours. venous occlusion plethysmography	—

Secondary

Measure	Time frame
Plasma glucose level before and at 30, 60, and 120 minutes after sugar ingestion. Plasma glucose level was measured by Hexokinase/ G-6-PDH,Serum insulin level before and at 30, 60, and 120 minutes after sugar ingestion. Serum insulin level was measured by Chemiluminescence immunoassay (CLIA),Oxidative stress makers before and at 30, 60, and 120 minutes after sugar ingestion. DNPH assay, ABTS and DPPH assay	—

Measure

Time frame

Plasma glucose level before and at 30, 60, and 120 minutes after sugar ingestion. Plasma glucose level was measured by Hexokinase/ G-6-PDH,Serum insulin level before and at 30, 60, and 120 minutes after sugar ingestion. Serum insulin level was measured by Chemiluminescence immunoassay (CLIA),Oxidative stress makers before and at 30, 60, and 120 minutes after sugar ingestion. DNPH assay, ABTS and DPPH assay

—

Countries

Thailand

Contacts

Public ContactManta Korakot

Faculty of Medicine, Chulalongkorn University

manta-ta@hotmail.com0984678808

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026