A comparison of the efficacy and safety of 10% Salicylic and 10% urea cream in the treatment of childhood acanthosis nigricans

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20201123003

Enrollment

Registered

2020-11-23

Start date

2020-12-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acanthosis nigricans Acanthosis nigricans&#44

Interventions

To assess the efficacy of 10% urea cream ,To assess the efficacy of 10% salicylic

Active Comparator Drug,Active Comparator Drug

10% urea cream,10% salicylic cream

Eligibility

Sex/Gender

All

Age

13 Years to 18 Years

Inclusion criteria

Inclusion criteria: The participants aged over 13 years with a diagnosis of acanthosis nigricans

Exclusion criteria

Exclusion criteria: - Vulnerable skin diseases - Infectious skin diseases - Other recent diseases involving the neck - Other serious medical disorders e.g. DM, liver disease - Any patients having received other therapies for up to 4 weeks prior to enrollment. - Photosensitive skin - Immunocompromised host - Pregnancy and lactation - Receiving oral retinoids - Neck tattoo - Allergy to salicylic acid

Design outcomes

Primary

Measure	Time frame
The efficacy week 0, 2, 4 and week 8 The Mexameter MX18	—

Secondary

Measure	Time frame
The efficacy week 0,2,4,8 investigatorâ€™s global evaluation (IGE) ,Side effect week 0,2,4,8 cutaneous irritation grading scales	—

Countries

Thailand

Contacts

Public ContactWatcharachai Kangvanskol

Faculty of Medicine, Srinakharinwirot University

watcharachai.kv@gmail.com0815935232

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026