Patient undergoing elective cardiac surgery Nefopam, cardiac surgery
Conditions
Interventions
Paracetamol 10mg/kg add nefopam 20 mg in normal saline up to 100 ml iv drip in 1 hour q 6 hours for 24 hours,Normal saline 100 ml iv drip in 1 hour q 6 hours for 24 hours
Experimental Drug,Placebo Comparator Drug
Multimodal ,Conventional
Sponsors
King chulalongkorn memorial hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Patients undergoing elective cardiac surgery e.g. CABG or Single valve repair 2.ASA II-III Cardiac risk index more than 3
Exclusion criteria
Exclusion criteria: 1.History of drug allergy which is used in this study e.g. paracetamol nefopam 2.unable to use IV PCA device 3.Echo: EF < 40% CHF cardiomegaly 4.current use of MAO inhibitors drug 5.liver cirrhosis or ESRD 6.epilepsy of history of seizures 7.history of acute angle glaucoma 8.High risk for urinary retention e.g. BPH
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score(rest, movement) 24 hrs, 48 hrs, 72 hrs, 96 hrs VAS,Triflow performance 48hrs, 72 hrs, 96hrs Scale of triflow performance ,Fentanyl consumption 24 hrs, 48 hrs Total dose (mcg) | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative nausea and vomiting 48 hrs, 72 hrs, 96 hrs Record number of Postoperative nausea and vomiting ,Postoperative derilium 24 hrs, 48hrs, 72hrs, 96hrs Record Confusion Assessment Method for the ICU(CAM ICU),Sedation score 24hrs, 48hrs Record The university of Michigan sedation scale (UMSS),Heart rate, blood pressure During infuse medications 1 hrs Record vital signs q 5 min | — |
Countries
Thailand
Contacts
Public ContactAPAPIT LAOPORN
Faculty of medicine, Chulalongkorn university
Outcome results
None listed