Serum bone marker concentrations in children and adolescents with 21-hydroxylase deficiency Bone mineral density in children and adolescents with 21-hydroxylase deficiency Congenital adrenal hyperplasia Children and adolescents Serum bone markers Bone mineral density
Conditions
Interventions
Children and adolescents with classic 21-hydroxylase deficiency
Other
Congenital adrenal hyperplasia children and adolescents
Sponsors
Research affairs, Faculty of Medicine, Khon Kaen University
Eligibility
Sex/Gender
All
Age
8 Years to 24 Years
Inclusion criteria
Inclusion criteria: 1. Children and adolescents ages 8-20 years 2. Diagnosed with classic 21-hydroxylase deficiency: 17-hydroxyprogesterone >10,000 ng/dl and peak cortisol <18 ug/dl after 250-ug ACTH test 3. Treated and follow up at Khon Kaen University Hospital
Exclusion criteria
Exclusion criteria: Participants with the following conditions will be excluded: 1. Diseases or medications affecting bone and vitamin D metabolism except glucocorticoid, calcium and vitamin D 2. Pathological fracture 3. Current or recent (< 6 months) fractures or wearing prostheses or instruments around the BMD measurement site 4. Deformity of the bone at the BMD measurement site 5. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum osteocalcin Baseline ELISA,Lumbar bone mineral density Baseline, 6-24 months DXA,Serum type-I collagen C-terminal telopeptide (CTX) Baseline ELISA | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum dickkopf-1 Baseline ELISA | — |
Countries
Thailand
Contacts
Public ContactPattara Wiromrat
Khon Kaen University
Outcome results
None listed