ovulation rate serum progesterone more than 3 ng/ml
Conditions
Interventions
Letrozole 2.5 mg/day plus clomiphene citrate 50 mg/day for 5 days on day3-
7 of cycle,Clomiphene citrate 50 mg/day for 5 days on day3-
7 of cycle
Experimental Drug,Active Comparator Drug
Letrozole plus clomiphene citrate,Clomiphene citrate alone
Sponsors
Faculty of medicine, Siriraj Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Women age between 18 and 40 years old 2. Infertile 3. Chronic anovulation (cycle length more than 35 days or diagnosed with PCOS) 4. Thai
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Received letrozole or clomiphene citrate within 3 month prior 3. Other causes of infertile, e.g. thyrotoxicosis, hyperprolactinemia 4. Uncontrolled underlying disease such as uncontrolled diabetes mellitus, uncontrolled hypertension, CA cervix 5. Allergic or contraindication to letrozole or clomiphene citrate 6. Husband has total motile sperm count less than 10 million
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ovulation rate day 21 or 22 of cycle in patients with negative urinary LH test or 7 days after positive urinary LH serum progesterone in ng/ml | — |
Secondary
| Measure | Time frame |
|---|---|
| side effect of medication after complete medication course inquiry questionnaires,Conception rate seven days after positive serum progesterone or day 35 of cycle if negative serum progesterone Urine pregnancy test,Clinical pregnancy 7 weeks after LMP Fetal heart beat,number of Dominant follicle day 12-14 of cycle Transvaginal ultrasound | — |
Countries
Thailand
Contacts
Public ContactSirikul Tanpong
Siriraj hospital
Outcome results
None listed