rate of respiratory distress syndrome late preterm,
Conditions
Interventions
Dexamethasone 6 mg IM every 12 hours until delivery,NSS 1.5 ml IM every 12 hours until delivery
Active Comparator Drug,Placebo Comparator No treatment
Dexamethasone ,normal saline
Sponsors
none
Eligibility
Sex/Gender
Male
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: Criteria for inclusion in the study were women (a) had preterm labor defined as regular uterine contractions before 37 weeks accompanied by a change of cervical dilatation, effacement, or both, or initial presentation with regular contractions and cervical dilatation at least 2 cm (16) or (b) had spontaneous rupture of membranes (preterm PROM), diagnosed by pooling of fluid at posterior fornix with speculum examination, positive cough test and positive alkaline pH test or (c) had fetal or maternal indications for delivery between 34 and 36+6 weeks gestation, such as placenta previa or fetal growth restriction.
Exclusion criteria
Exclusion criteria: We excluded women with multiple gestations, those who had received a previous course of corticosteroids, infection or chorioamnionitis (fetal tachycardia>160 bpm, maternal fever > 37.8 °C and foul smelling amniotic fluid) during labor, overt diabetes mellitus, gestational diabetes mellitus, cervical dilation more than 5 centimeters, thrombocytopenia, allergy to corticosteroids, preeclampsia severe feature and HELP syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rate of neonatal respiratory distress syndrome 72 hours clinical signs and radiography | — |
Secondary
| Measure | Time frame |
|---|---|
| the need for CPAP, the NICU admission, Apgar score 1 and 5 min, TTN, IVH, adverse effects 7 days ventilator, blood sugar, clinical signs | — |
Contacts
Public ContactPimon Kongprayoon
Department of Obstetrics and Gynecology, Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand
Outcome results
None listed