Bone Mineral Density and Dickkopf-1 in Adolescents with Non-Deletional Hemoglobin H Disease

Bone Mineral Density and Its Associations with Markers of Oxidative Stress in Children and Adolescents with Hemoglobin H with Constant Spring

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20201108001

Enrollment

Registered

2020-11-08

Start date

2021-06-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone mineral density in children and adolescents with transfusion-dependent hemoglobin H with Constant Spring compared with healthy children Association between oxidative stress biomarkers and BMD Alpha-thalassemia, Hemoglobin H-Constant Spring, Bone mineral Density

Interventions

Children and adolescents with hemoglobin H with Constant Spring with regular blood transfusion,Age and sex&#45

matched Healthy children

Other,Other

Hemoglobin H with Constant Spring group,Healthy control group

Eligibility

Sex/Gender

All

Age

10 Years to 20 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for the thalassemia group 1. Ages 10-20 years 2. Diagnosed with hemoglobin H with Constant Spring (Hb H/CS) 3. Diagnosed with transfusion-dependent Hb H/CS requiring regular blood transfusion every 4-6 weeks to raise Hb levels >7 g/dL. Generally, patients with 3 out of the following 5 criteria required red blood cell transfusion: 1) anemic symptoms, 2) Hb equal or more than 7 g/dl, 3) growth failure 4) marked hepatosplenomegaly, 5) homolytic crisis equal or more than 3 episodes/year, 6) Height and weight 10-95%tile, 7) BMI 10-85%tile, 8) Treated and follow up at Khon Kaen University Hospital

Exclusion criteria

Exclusion criteria: Participants with the following conditions will be excluded: 1. Diseases or medications affecting bone and vitamin D metabolism except calcium and vitamin D supplement 2. Pathological fracture 3. Current or recent fractures (<6 months) or wearing prostheses or instruments around the BMD measurement site 4. Deformity of the bone at the BMD measurement site 5. Pregnancy

Design outcomes

Primary

Measure	Time frame
Lumbar and total body less head bone mineral density This is a cross-sectional study (only 1 time point - on study visit) dual-energy x-ray absorptiometry,Stable serum oxidative stress biomarker This is a cross-sectional study (only 1 time point - on the study visit) ELISA, fluorometric assay	—

Secondary

Measure	Time frame
Serum malondialdehyde This is a cross-sectional study (only 1 time point - on study visit) Fluorometric assay	—

Countries

Thailand

Contacts

Public ContactPattara Wiromrat

Khon Kaen University

patwiro@kku.ac.th0867168485

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026