Efficacy and safety of using combination of non-insulated microneedle radiofrequency alone compared to combination with polynucleotides for the treatment of periorbital wrinkle. A pilot study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20201105007

Enrollment

Registered

2020-11-05

Start date

2020-11-09

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periorbital wrinkle non&#45

Interventions

insulated microneedle radiofrequency with polynucleotides

Patients receive 3 intervention biweekly combination of non&#45

insulated microneedle radiofrequency alone compared to combination with polynucleotides for the treatment of periorbital wrinkle&#44

split&#45

face study

Experimental Drug

Non&#45

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Fitzpatrick skin type 3-5 Class 1-2 of Fitzpatrickâ€™s Classification of Facial Wrinkling (Periorbital)

Exclusion criteria

Exclusion criteria: Allergy to hyaluronic acid or polynucleotide Pregnancy, Breast feeding, or postpartum within 3 months Has skin infection at periorbital area Using steroid, anticoagulant, anti platelet and ginkgo Smoking History of hypertrophic scar or keloid

Design outcomes

Primary

Measure	Time frame
Efficacy of using combination of non-insulated microneedle RF with polynucleotides baseline, 2 wk, 4 wk, 6 wk, 8 wk, 12 wk, 16 wk, 28 wk Photograph, Antera, Visioscan, Cutometer, Mexameter	—

Secondary

Measure	Time frame
Safety of using combination of non-insulated microneedle RF with polynucleotides baseline, 2 wk, 4 wk, 6 wk, 8 wk, 12 wk, 16 wk, 28 wk VAS, Side effect	—

Countries

Thailand

Contacts

Public ContactYanisorn Nanchaipruek

Faculty of Medicine Siriraj Hospital, Mahidol University

yanisorn.nan@mahidol.ac.th0946949454

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Efficacy and safety of using combination of non&#45;insulated microneedle radiofrequency alone compared to combination with polynucleotides for the treatment of periorbital wrinkle. A pilot study