-
Conditions
Interventions
Experimental Device
Sponsors
Faculty of medicine
Faculty of medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Systemic sclerosis, age >/= 18 years old 2.Abnormal increased CPK enzyme level above upper normal limited (> 200 IU/L). 3.Muscle weakness ≤grade IV based on manual muscle testing.
Exclusion criteria
Exclusion criteria: 1.Deny performing muscle biopsy. 2.Ongoing immunosuppressive drug and unable to stop the drug due to prevent disease control flare up during the time of MRE examination (low dose steroid equivalent with prednisolone ≤15 mg/d is allow during MRE examination) 3.Having contraindication to perform muscle biopsy 4.Underlying bleeding disorder or coagulopathy 5.Take any anticoagulant, antiplatelet, or other medicines that affect blood clotting 6.Infection of the biopsy site 7.Absolute contraindication to perform MRI and MRE. 8.Pregnancy or lactation 9.Advanced stage of cancer 10.Sepsis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| muscle stiffness at study date shear modulus, wave length, decay constant | — |
Secondary
| Measure | Time frame |
|---|---|
| differences between myositis and myopathy at study date shear modulus, wave length, decay constan | — |
Countries
Thailand
Contacts
Public ContactPunthip Thammaroj
Faculty of Medicine, Khon Kaen University
Outcome results
None listed