Metabolic Syndrome metabolic syndrome diabetes diet eggs cholesterol weight loss
Conditions
Interventions
consume carbohydrate < 10% and 3 whole eggs supplement per day in 12 weeks,consume carbohydrate < 10% and 6 white eggs supplement per day in 12 weeks,decrease consumption of diet from typical (decreas
Yolk ketogenic diet,White ketogenic diet,Control group
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
National Research Council of Thailand (NRCT)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.weight stable > 3 months (changing < 5%) 2.three or more of the following five criteria are met 2.1 waist circumference ≥ 90 cm (men) or ≥ 80 cm (women) 2.2 fasting blood sugar ≥ 100 mg/dl 2.3 fasting triglyceride (TG) level ≥ 150 mg/dl 2.4 fasting high-density lipoprotein (HDL) cholesterol level ≤ 40 mg/dl (men) or ≤ 50 mg/dl (women) 2.5 blood pressure over 130/85 mmHg 3.can consume food that provided in project 4.healthy
Exclusion criteria
Exclusion criteria: 1.consume drugs i.e. weight loss drugs, herbal pills, asthma drugs, steroid drugs, thyroid drugs, insulin injections, SGLT1 inhibitors drugs, SGLT2 inhibitors drugs, sulfonylurea drugs, blood lipid-lowering drugs 2.people who exercise vigorously (> 150 minutes per week) 3.people who are or have weight loss by consuming less than 30% of carbohydrates, or are losing weight by other methods or who have eaten a specific diet as prescribed by a doctor within the past 6 months 4.people who drink alcohol more than once a week 5.people who had a LDL level within 6 months > 190 mg/dl 6.fasting blood glucose levels > 250 mg/dl and using diabetes drugs other than metformin 7.people with heart disease, type 1 diabetes, renal impairment > level 3A 8.history of cancer, lung disease, gastrointestinal disease 9.people who smoke, people with eating disorder, people who have received psychiatric drugs 10.become a volunteer in a research project that is conducting a study related to food consumption 11.people who are unable to keep up with the treatment or are expected to be absent in this area for the next 4 months 12.pregnancy or breastfeeding 13.egg allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in weight following dietary intervention Baseline and after 12 weeks weight (kg) analysis,Changes in body mass index following dietary intervention Baseline and after 12 weeks body mass index (kg/m^2) analysis,Changes in waist circumference following dietary intervention Baseline and after 12 weeks waist circumference (cm) analysis,Changes in lipid profiles concentration following dietary intervention Baseline and after 12 weeks Triglycerides (mg/dl), Cholesterol (mg/dl), HDL-cholesterol (mg/dl) and LDL-cholesterol (mg/dl) conc,Changes in blood glucose and insulin concentration following dietary intervention Baseline and after 12 weeks HbA1C (%), glucose (mg/dl) and insulin (mg/dl) concentration analysis,Changes in betahydroxybutirate concentration following dietary intervention Baseline and after 12 weeks betahydroxybutirate (mmol/L) concentration analysis,Changes in electrolytes concentration following dietary intervention Baseline and after 12 weeks Na+ (mg/dl), K+ (mg/dl), Cl- (mg/dl) and HCO3- (mg/dl) concentration analysis,Changes in physical activity Baseline and after 12 weeks physical activity (MET-minutes/week) collect data by using questionnaires,Change from baseline Glycemia at 180 minutes Minutes after intake of 75 g glucose: 0, 30, 60, 90, 120, 180 glucose (mg/dl),Change from baseline Insulin at 180 minutes Minutes after intake of 75 g glucose: 0, 30, 60, 90, 120, 180 insulin (μU/ml) | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in blood pressure Baseline and after 12 weeks Systolic and Diastolic blood pressure (mmHg),Changes in fasting leptin levels Baseline and after 12 weeks leptin (mg/dl) concentration analysis,Changes in energy intake following dietary intervention Baseline and after 12 weeks energy (kcal),Changes in carbohydrate following dietary intervention Baseline and after 12 weeks carbohydrate (g),Changes in protein intake following dietary intervention Baseline and after 12 weeks protein (g),Changes in fat intake following dietary intervention Baseline and after 12 weeks fat (g) | — |
Countries
Thailand
Contacts
Public ContactKorapat Mayurasakorn
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed