Acute cystitis Kidney transplant recipients Cystitis Kidney transplant recipients Fosfomycin trometamol
Conditions
Interventions
Fosfomycin 3g oral 2 doses every 72 hr
,other antibiotics for 7 days
Experimental Drug,Active Comparator Drug
Fosfomycin trometamol,Conventional antibiotics
Sponsors
Research department, Faculty of Medicine Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Kidney transplant recipients age ≥ 18 years Suspected acute cystitis -Pyuria; urine WBC ≥ 5 cells/HPF -Bacteriuria; any bacteria found -Necessitate antibiotic treatment by primary physicians
Exclusion criteria
Exclusion criteria: Patients with sign or symptoms of upper urinary tract infection or acute pyelonephritis (fever, nausea and vomiting, flank pain, kidney graft tenderness) History of Fosfomycin trometamol allergy kidney function creatinine clearance below 10 ml/min patients with primary graft failure required continuous renal replacement therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resolution of pyuria 2 weeks after enrollment urinalysis | — |
Secondary
| Measure | Time frame |
|---|---|
| No antibiotic retreatment 3 months after enrollment patients' medical record review | — |
Countries
Thailnad
Contacts
Public ContactPakpoom Phoompoung
Faculty of medicine Siriraj hospital
Outcome results
None listed