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Effect of dexamethasone or ibuprofen-acetaminophen combination for pain management in symptomatic apical periodontitis during COVID-19 outbreak: a retrospective cohort study

Effect of dexamethasone or ibuprofen-acetaminophen combination for pain management in symptomatic apical periodontitis during COVID-19 outbreak: a retrospective cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20201027002
Enrollment
50
Registered
2020-10-27
Start date
2020-10-04
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

tooth pain Pain

Interventions

ibuprofen 600 mg + acetaminophen 500 mg twice for 3 days,4 mg dexamethasone twice for 1 day
Prevention,Prevention
ibuprofen + acetaminophen,dexamethasone

Sponsors

None listed

Eligibility

Sex/Gender
All
Age
0 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1) age, 18–65 years, 2) maxillary\ mandibular molar tooth with symptomatic apical periodontitis and vital pulp, 3) the given medications were the same (ibuprofen 600 mg + acetaminophen 500 mg twice for 3 days or 4 mg dexamethasone twice for 1 day) and 4) complete clinical/radiographic data and pain levels at baseline, 6, 12, 18, 24, 48 and 72 hours.

Exclusion criteria

Exclusion criteria: 1) necrotic pulp, 2) periapical index score 4 and 5 proposed by Ørstavik et al. [12], 3) pregnancy and systemic disease or allergic reactions, 4) sensitivity or adverse reactions to medicines, 5) taken any analgesics or anti-inflammatory drug within the last 3 days, 6) swelling or acute/chronic abscess, 7) active orthodontic appliances and 8) multiple carious teeth.

Design outcomes

Primary

MeasureTime frame
pain a week vas

Secondary

MeasureTime frame
pain on percussion 1 week vas

Countries

Türkiye

Contacts

Public ContactHakan Arslan

Medeniyet University

dt_hakan82@hotmail.com+905303492612

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026