Comparison Efficacy and Safety of Koklan Mixture Formula 3 and Diclofenac for Relieving Pain in Primary Knee Osteoarthritis

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20201020010

Enrollment

Unknown

Registered

2020-10-20

Start date

2020-10-12

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis is a very common disease in the elderly society. Changes in the articular cartilage cause knee deterioration&#44

Interventions

The KoKlan Mixture Formula 3 IS a National Drug Information from Thai traditional medicine and has sufficient scientific data of pharmacology properties supporting the pain relieving&#44

anti&#45

inflammatory results and clinical study also showed support for the safety of using this medicine instead of NSAIDs. KoKlan (Scientific Name: Mallotus Repandus (Willd.) Mull.Arg. Family: Euphorbiacea

inflammatory and analgesic,In general&#44

Diclofenac&#44

which belongs to NSAIDs&#44

has analgesic and anti&#45

inflammatory effects. Although Diclofenac is often prescribed&#44

it conveys high incidences of side effects especially in stomach ulcers.

Experimental Drug,Active Comparator Drug

Koklan Mixture Formula 3 ,Diclofenac

Eligibility

Sex/Gender

All

Age

50 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1) age between 50-70 years old, no sex limitation. 2)Has diagnosed with Primary-KOA by modern medicine doctor and Thai Tradition medicine doctor and Oxford Knee Score with pain level 1-2 (score of 20-39.) This is a mild to moderate pain level. 3)No personal severe chronic disease: ulcer, heart, liver, lung, or kidney diseases. 4) Does not take NSAID pain reliever in the last 1 week before participates in the project.

Exclusion criteria

Exclusion criteria: 1) History of medical allergy used during investigation 2) Severe knee osteoarthritis and currently using NSAIDs

Design outcomes

Primary

Measure	Time frame
Pain relieving 1,3,7,14,21 days Comparision of KoKlan Mixture Formula 3 and Diclofenac	—

Secondary

Measure	Time frame
Efficacy and Safety 14 days Oxford Knee Score ,WOMAC, Knee range of motion, laboratory blood	—

Contacts

Public ContactRenu Pongsaree

Graduate School , Suansunandha Rajabhat University

renu622009@gmail.com0816365809

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026