Alzheimer’s disease Whole genome sequencing Human genome Transcriptome sequencing
Conditions
Interventions
Thai volunteers aged 55-
85 years. Male or female and no disease Alzheimer'
s. According to the evaluation criteria Neuropsychiatric Tests
,Thai volunteers aged 55-
85 years. Male or female and with mild cognitive impairment. According to the evaluation criteria Neuropsychiatric Tests.,Thai volunteers aged 55-
85 year. Male or female and with mild dementia,
moderate dementia . According to the evaluation criteria Neuropsychiatric Tests
Screening,Screening,Screening
The Volunteers without Alzheimer'
s disease,The Volunteers with mild cognitive impairment,The Volunteers with mild dementia and moderate dementia
Sponsors
Governance
N/A, N/A
Eligibility
Sex/Gender
All
Age
55 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Diagnostic of clinical assessment criteria neuropsychiatric tests 2.No psychiatric diseases or using drugs that affect the nervous system 3.Agree to participate in research projects
Exclusion criteria
Exclusion criteria: 1.Physical diseases and/or brain diseases affecting the study. ex. chronic kidney disease, chronic liver disease, diabetes mellitus at HbA1C more than or equal to 7 2.Pregnant or breastfeeding women. 3.Those who can not or do a CT and MRI of the brain. 4.Those in the treatment or monitoring the disease to exposure to radiation. 5.The suspect dementia from other causes ex. depression, ischemic stroke. 6. Those who screened MRI brain found lesions in supcortical white matter more than or equal to 10 mm. or lesions less than 10 mm./More than or equal to 3 lesions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| genetic code of alzheimer's disease 5 year laboratory test, clinical data,The implementation of Alzheimer's disease in Thai population 5 year Neuropsychiatric test, Laboratory test, Clinical data,Brain function and perform brain mapping. 5 year MRI, Laboratory test, Clinical data,Brain imaging 5 year PET/CT-Scan, Laboratory test, Clinical data,Genetic code of Alzheimer's disease 5 year Next Generation Sequencing Technology, Laboratory test, Clinical data,genetic code of alzheimer's disease 5 year MRI,Linking gut microbiota, Nutritional related to Alzheimer’s disease 5 year Nutritional status, 24-hour dietary recall,determination of physical activity, Laboratory test, Clin,Genetic code of Alzheimer's disease 5 year Whole Genome Sequencing, Laboratory test, Clinical data | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Public ContactKasiruck wittayasak
Unaffiliated
Outcome results
None listed