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Significant clinical efficacy of group interpersonal psychotherapy (IPT) as add-on treatment for depressive disorder: a randomized controlled trial.

Significant clinical efficacy of group interpersonal psychotherapy (IPT) as add-on treatment for depressive disorder: a randomized controlled trial.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20201016003
Enrollment
Unknown
Registered
2020-10-16
Start date
2018-10-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depressive Symptoms (Scores on The Hamilton Depression Rating Scale&#44

Interventions

The interventions on the expeimental group consisted of interpersonal group psychotherapy (IPT&#45
G)&#44
antidepressants&#44
and care as usual (CAU). IPT&#45
G was group interpersonal psychotherapy conducted with 10–12 patients in each group. group IPT was conducted in 12 weekly sessions&#44
60– 90 minutes each. The treatment comprised 1) an initial phase&#44
2) an intermediate or middle phase&#44
3) the termination phase. The initial phase aimed to build a therapeutic relationship and making a treatment contract. To associate interpersonal problems with the patients’ depressive symptoms. The
exploratory techniques&#44
use or encouragement of affect&#44
communication analysis&#44
role playing&#44
problem solving and decision analysis&#44
task assignment and homework&#44
use of therapeutic relationships for solving interpersonal problems. The process and techniques of group therapy were also applied in this phase such as going around&#44
feedback&#44
and practicing. The termination phase (W16) aimed to review the progression and the success of the treatment&#44
discussion of the new problem&#45

Sponsors

None
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with an acute phase of major depressive disorder (MDD) as diagnosed using DSM-5 criteria, aged above 18 years, both sexes, and newly diagnosed within 3 months, with Thai HRSD ≥ 16 (moderate to severe depression) were included to the study.

Exclusion criteria

Exclusion criteria: Patients with the followings were excluded: (1) major depressive disorder with psychotic features; (2) schizophrenia and other psychotic disorders; (3) bipolar disorders; (4) dementias; (5) organic mental disorders; (6) substance-induced mood disorders, as assessed by psychiatric history taking and mental status examination by the investigators.

Design outcomes

Primary

MeasureTime frame
Depressive Symptoms (Scores on The Hamilton Depression Rating Scale, HDRS) at the beginning (week 0), week 4, week 8, week 12, after the program (week 16) The Hamilton Depression Rating Scale (HDRS)

Secondary

MeasureTime frame
N/A N/A N/A

Contacts

Public ContactPeeraphon Lueboonthavatchai

Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

peeraphon_tu@yahoo.com02-2564000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026