atrophic acne scars atrophic acne scars microneedles vitamin C retinaldehyde
Conditions
Interventions
Vitamin C and retinaldehyde-
loaded dissolvable microneedles will be applied at acne scars on one side of face,Dissolvable microneedles alone will be applied at acne scars on another side of the same patient'
s face
Experimental Drug,Placebo Comparator No treatment
vitamin C and retinaldehyde-
loaded dissolvable microneedles ,microneedles without medication
Sponsors
Dermatology division, Department of internal medicine, King Chulalongkorn Memorial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.male or female age over 18 years old 2.Symmetric mild-moderate atrophic acne scars on both sides of face 3.having the scars for more than 6 months but not more than 5 years 4.good compliance to the protocol
Exclusion criteria
Exclusion criteria: 1.patients with history of allergic reaction to retinoid or vitaminC 2.patients who are preganacy or lactating 3.patients with photosensitivity rash, skin infection or other dermatitis in the area of treatment 4.patients who cannot follow the protocol 5.previous facial aesthetic procedures such as filler injection, lasers in the area of treatment within 6 months prior to the recruitment 6.patients with history of hypertrophic scars
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acne scar depthness and melanin pigment; acne scar scores month 0,1,3,6 Antera 3D ® ; Qualitative scarring grading system | — |
Secondary
| Measure | Time frame |
|---|---|
| side effects and safety of vitamin C and retinaldehyde-loaded dissolvable microneedles month 0,1,3,6 Visual Analogue Scale (VAS) for pain score, tightness and pruritus score, patient satisfaction score | — |
Countries
Thailand
Contacts
Public ContactChanat Kumtornrut
Faculty of Medicine, Chulalongkorn university
Outcome results
None listed