Cardiorenal syndrome type 1 (AKI stage 2 from acute worsening cardiac function) Cardiorenal syndrome type 1 peritoneal dialysis AKI
Conditions
Interventions
start pd within 24 hour after randomization (diagnosed AKI stage 2),start pd within 72 hour after randomization (persistent AKI stage 2-3) or start pd when had a conventional indication for dialysis
Experimental Procedure/Surgery,Active Comparator Procedure/Surgery
early start PD,conventional start PD
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 999 Years
Inclusion criteria
Inclusion criteria: - Age >= 18 years old - AKI stage 2 (KDIGO criteria) with cardiorenal syndrome type1 - Respiratory failure (on ETT and need mechanical ventilator)
Exclusion criteria
Exclusion criteria: - Secondary peritonitis - Need emergency dialysis (K>6 mEq/L, HCO3 < 12 mmol/L, FiO2/PaO2 < 200 with pulmonary edema, physician judgement that required emergency dialysis) - Morbid obesity (BMI > 35 kg/m2) - CKD stage 4-5 - Active infection with sepsis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 30-day mortality 30 days after randomization death or alive | — |
Secondary
| Measure | Time frame |
|---|---|
| 5-day fluid balance end of day 5 after randomization ml,Major adverse kidney event at 90 days (MAKE90) 90 day death or dialysis dependence or serum creatinine persistent increase more than 2x from baseline,serum creatinine at hospital discharge, 30 and 90 days after randomization mg/dl,PD related complication During first 5 PD sessions PD catheter insertion complication, PD related infectious, PD related metabolic disturbance ,5-day sodium removal end of day 5 after randomization mmol/l of sodium from urine and PD | — |
Countries
Thailand
Contacts
Public ContactWatanyu Parapiboon
Maharat Nakhonratchasima Hospital
Outcome results
None listed