Hypoxic hepatitis: incidence, biochemical markers, and risk factor of mortality: a cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20200925005

Enrollment

4000

Registered

2020-09-25

Start date

2019-10-30

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypoxic hepatitis Hypoxic hepatitis Ischemic hepatitis Shock liver Incidence

Interventions

1. Adult (more than or equal to 18 years old) 2. Admitted to internal medicine ward and ICU of Siriraj hospital during 2008&#45

2018 3. Diagnosis as hypoxic hepatitis (defined by AST or ALT more than or equal to 20 times of upper normal limit and has been exclude other condition e.g. drug induced&#44

chemical or toxic&#45

related liver injury&#44

or acute viral injury

Basic Science

Total cases in admission between 2008&#45

2018

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Adult (more than or equal to 18 years old) 2. Admitted to internal medicine ward and ICU of Siriraj hospital during 2008-2018 3. Diagnosis as hypoxic hepatitis (defined by AST or ALT more than or equal to 20 times of upper normal limit and has been exclude other condition e.g. drug induced, chemical or toxic-related liver injury, or acute viral injury

Exclusion criteria

Exclusion criteria: 1. Drug induced, chemical or toxic-related liver injury defined by 1.1. Diagnosis by physician (in consider of history of risk, dose, and duration) or 1.2. History of paracetamol intake more than or equal to 150 mg/kg/day or 1.3. Paracetamol level in toxic level of nomogram 2. Acute viral injury defined by 2.1. anti-HAV IgM positive or 2.2. anti-HBc IgM positive or 2.3. Recent conversion of anti-HCV from negative to positive concurrent with HCV RNA positive 3. History of liver surgery (including resection and liver transplantation)

Design outcomes

Primary

Measure	Time frame
Incidence of hypoxic hepatitis 10 years (2008-2018) Percentage of hypoxic hepatitis cases and total cases in admission	—

Secondary

Measure	Time frame
Biochemical markers of hypoxic hepatitis 10 years (2008-2018) Time change of biochemical markers by day in hypoxic hepatitis cases,Risk factor of mortality in hypoxic hepatitis 10 years (2008-2018) Percentage	—

Countries

Thailand

Contacts

Public ContactWutthiphat Amornmongkhol

Siriraj hospital

nickz_c@hotmail.com0817338702

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026