Does duloxetine reduces pain in total knee arthroplasty? Randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20200925002

Enrollment

Registered

2020-09-25

Start date

2020-05-18

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain score and function after take duloxetine compare without duloxetine group Pain, TKA, Duloxetine

Interventions

Duloxetine 30 mg 1 tab oral pc at dinner,placebo

Active Comparator Drug,Placebo Comparator Drug

Duloxetine,placebo

Eligibility

Sex/Gender

All

Age

40 Years to 90 Years

Inclusion criteria

Inclusion criteria: OA knee who undergoing unilateral TKA Age > 40 years Comply with the protocol

Exclusion criteria

Exclusion criteria: Allergy to duloxetine Allergy to medication protocol Severe liver and renal function Secondary OA knee Poor control DM

Design outcomes

Primary

Measure	Time frame
pain score day1,3 after sugery, 2weeks, 6 weeks, 3month VAS score	—

Secondary

Measure	Time frame
functional score 6weeks and 3month Oxford knee score ,KROOS,flexion of knee 6 weeks and 3 month metric,morphine consumption in hospital period metric,Adverse events 3 month Nausea ,dry lips ,dizziness ,constipation	—

Countries

Thailand

Contacts

Public ContactJakkarin Phunphakchit

Department of orthopaedics, Faculty of medicine ,Thammasat university

kakarjin@gmail.com0927429536

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026