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The effect of skin care product containing heat-treated probiotic, fructooligosaccharide and galactooligosaccharide on irritation, moisturization, transepidermal water loss, oiliness, skin gloss, skin color, wrinkle, skin microbiome, and satisfaction in volunteers

The effect of skin care product containing heat-treated probiotic, fructooligosaccharide and galactooligosaccharide on irritation, moisturization, transepidermal water loss, oiliness, skin gloss, skin color, wrinkle, skin microbiome, satisfaction

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
TCTR
Registry ID
TCTR20200917006
Enrollment
100
Registered
2020-09-17
Start date
2020-09-25
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy men and women&#44

Interventions

skin care product without active ingredients,Skin care product containing Heat&#45
treated Lactobacillus spp.&#44
Fructo Oligosaccharides And galacto oligosaccharides,Skin care product containing Heat&#45
treated Bifidobacterium spp.&#44
Fructo Oligosaccharides and galacto oligosaccharides ,Skin care product containing Heat&#45
Heat&#45
Fructo Oligosaccharides and galacto oligosaccharides
Placebo Comparator Other,Active Comparator Other,Active Comparator Other,Active Comparator Other
Group 1,Group 2,Group 3,Group 4

Sponsors

Innovation and technology assistance program, Thailand Science Park
Lead Sponsor
Innovation Center for Holistic Health&#44
Collaborator
Nutraceuticals and Cosmeceuticals&#44
Collaborator
Chiangmai Univeristy
Collaborator

Eligibility

Sex/Gender
All
Age
20 Years to 65 Years

Inclusion criteria

Inclusion criteria: - No skin diseases, tattoos or wounds appear on the test site - Not allergic to the ingredients of products after receiving the test product - No pregnancy or lactation - No midical history of autoimmune diseases - No symptoms that have to be hospitalized during the past 6 months - Good health and normal mental state - Have consent to participate - Volunteers who did not participate in other clinical tests in 3 months before - Have not taken the antibiotic 14 days before the program start

Exclusion criteria

Exclusion criteria: - Volunteers who need to apply products that affect moisture, oil, and other skin shine at the test site of the project During the experiment, such as cream or body lotion, hand cream and body oil, etc. - Volunteers taking medication related to chronic diseases or requiring antibiotics for a period of more than 14 days while participating in the project

Design outcomes

Primary

MeasureTime frame
Irritation on area of products After applying the product for 0,24 and 48 hours Patch test and Aramo Smart® ,Moisture Content After applying the product for 0,1,2,3,4,5 hours and 4 weeks MoistureMeter SC,Transepidermal Water Loss (TEWL) After applying the product for 0,1,2,3,4,5 hours and 4 weeks VapoMeter,Sebum Secretion After applying the product for 0,1,2,3,4,5 hours and 4 weeks Sebumscale,Skin Gloss After applying the product for 0,1,2,3,4,5 hours and 4 weeks Skin Gloss Meter (SGM) ,Microbiome on skin After applying the product for 0 and 4 weeks Skin swabing,Skin color After applying the product for 0 and 4 weeks Skin color meter ,Skin wrinkle After applying the product for 0,1,2,3,4,5 hours and 4 weeks Photography—

Secondary

MeasureTime frame
Satisfaction in volunteers After applying the product for 0 and 4 weeks Satisfaction in product—

Countries

Thailand

Contacts

Public ContactChaiyavat Chaiyasut

Faculty of Pharmacy, Chaing Mai University, Thailand

chaiyavat@gmail.com+66 53944340

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026