Dengue is a global problem and is common in more than 120 countries,
Conditions
Interventions
Treatment according World Health Organization guideline for Dengue Hemorrhagic Fever.,Continuous positive airway pressure (CPAP) therapy might reduce pleural effusion resolution time
Standard treatment arm,Continuous positive airway pressure (CPAP) therapy arm
Sponsors
Mahidol Oxford Research Unit
Mahidol Oxford Research Unit
Eligibility
Sex/Gender
All
Age
19 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age > 18 years; 2. Dengue infection confirmed by either antigen detection e.g. PCR for RNA, NS1Ag or antibodies detection e.g. IgM ELISA, paired IgG ELISA methods; 3. Newly detected pleural effusion of at least 2 centimeters detected by chest ultrasound at posterior part of right diaphragm in upright position in 24 to 48 hours after fever has disappeared.
Exclusion criteria
Exclusion criteria: 1. An underlying disorder causative of pleural effusion e.g. tuberculous effusion, malignancy effusion, cirrhosis, heart failure, etc. 2.Contraindication to CPAP, e.g., coma, shock or known intolerance for NIV/CPAP 3.Pregnancy 4.No informed consent 5. Cannot communicate with Thai or English language
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pleural effusion resolution time Time since newly detected pleural effusion till resolution of pleural effusion chest ultrasound | — |
Secondary
| Measure | Time frame |
|---|---|
| Dyspnea score Time since newly detected pleural effusion till resolution of pleural effusion Modified Borg Score | — |
Contacts
Public ContactChaisith Sivakorn
Faculty of Tropical medicine, Mahidol university
Outcome results
None listed