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The effects of Human neutrophil peptides (HNPs) on dermal fibroblasts and keratinocytes in 2D and 3D cell cultures

The effects of Human neutrophil peptides (HNPs) on dermal fibroblasts and keratinocytes in 2D and 3D cell cultures

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20200910003
Enrollment
Unknown
Registered
2020-09-10
Start date
2020-03-24
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy children

Interventions

None listed

Sponsors

Institutional Review Board, Faculty of Medicine, Chulalongkorn University
Lead Sponsor
Department of Microbiology&#44
Collaborator
Faculty of Science&#44
Collaborator
Chulalongkorn University
Collaborator

Eligibility

Sex/Gender
Male
Age
No minimum to 3 Months

Inclusion criteria

Inclusion criteria: Healthy children who are circumcised at King Chulalongkorn Memorial Hospital, Bangkok, Thailand

Exclusion criteria

Exclusion criteria: Children who are unhealthy such as immunodeficiency and infection

Design outcomes

Primary

MeasureTime frame
HNP1-3 on human dermal fibroblast and keratinocyte proliferation 24 hrs Methylene blue staining and LDH cytotoxicity assay ,HNP1-3 on collagen type I production in dermal fibroblast and claudin-1 expression in keratinocyte 48 hrs ELISA and western blot—

Secondary

MeasureTime frame
HNP1-3 on collagen type I production in dermal fibroblast and claudin-1 expression in keratinocyte 48 hrs ELISA and western blot—

Countries

Thailand

Contacts

Public ContactDirekrit Chiewchengchol

Faculty of Medicine, Chulalongkorn University

direkrit.c@chula.ac.th02-256-4132

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026