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Prediction of response to Erythropoiesis stimulating agents by erythropoietin level and gene mutations in Low-risk Myelodysplastic syndromes

Prediction of response to Erythropoiesis stimulating agents by erythropoietin level and gene mutations in Low-risk Myelodysplastic syndromes: Cross sectional study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20200909001
Enrollment
42
Registered
2020-09-09
Start date
2020-01-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myelodysplastic syndrome 1. Myelodysplastic syndrome 2. Erythropoietin level 3. Erythropoietin stimulating agent

Interventions

1. Hb is increased more than 1.5 g/dL 2. Decrease RBC transfusion than 4 unit/8 weeks ,Not fit in 1. Hb is increased more than 1.5 g/dL 2. Decrease RBC transfusion than 4 unit/8 weeks
Supportive Care,Supportive Care
Response to ESA,Unresponse to ESA

Sponsors

Ratchadaphiseksomphot Endowment Fund
Lead Sponsor
์None
Collaborator

Eligibility

Sex/Gender
All
Age
15 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. The patient who has diasnosed as Myelodysplastic syndrome during 1 January 2014 ถึง 31 January 2019 2562 2. The patient has age more than 15 years-old 3. IPSS-R score 0-4.5 (MDS low risk) 4. The patient was treated by Erythropoietin stimulating agent

Exclusion criteria

Exclusion criteria: 1. Therapy related MDS 2. History of pure red cell aplasia

Design outcomes

Primary

MeasureTime frame
EPO level After ESA 4-8 weeks Independent two-sample t-test—

Secondary

MeasureTime frame
Type of Gene mutation After ESA 4-8 weeks Chi square,Size of erythropoietin stimulating agent After ESA 4-8 weeks Mean of Erythropoietin stimulating agent in response group—

Countries

Thailand

Contacts

Public ContactSaroj Hattakitpanitchakul
Sarogeh@gmail.com0869807425

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026