Lung mass Mediastinal lymphadenopathy Cancer Lung nodule Consolidation Advanced fiberoptic bronchoscope miniprobe EBUS premedication dextromethorphan cough suppression Indian Gooseberry extract Emblica officinalis extract
Conditions
Interventions
Premedication with oral dextromethorphan and Emblica officinalis extract improve cough tolerance during advanced bronchoscopy,Premedication with oral dextromethorphan improve cough tolerance during ad
Placebo Comparator Drug,Placebo Comparator Drug,Placebo Comparator Drug,Placebo Comparator Drug
Placebo,Dextromethorphan,Emblica officinalis extract,Emblica officinalis extract and dextromethorphan
Sponsors
Division of Pulmonary Disease and Pulmonary Critical Care
Ratchadaphiseksomphot Endowment Fund
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients undergoing advanced fiberoptic bronchoscope at King Chulalongkorn Memorial hospital
Exclusion criteria
Exclusion criteria: Recent myocardial infarction or unstable angina within 6 weeks. Arrhythmia Stridor/ advanced central airway obstruction Moderate to severe hypoxemia(PaO2 < 60 mmHg.)or pulse oximetry < 90% Dextromethorphan allergy Discontinue antiplatelet < 5 days. Pregnancy and breastfeeding On Monoamine oxidase inhibitor Poor control diabetic mellitus OSA patients Dextromethorphan allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough score during the procedure during the procedure count cough sound during the procedure | — |
Secondary
| Measure | Time frame |
|---|---|
| Dose of midazolam during bronchoscopy during the procedure milligram during bronchoscopy,Duration of procedure during the procedure minute,Dose of lidocaine during bronchoscopy during the procedure microgram during bronchoscopy,Complicationduring and post procedure during and post the procedure events,Sore throat after procedure post procedure Visual analogue scale,Lowest desaturation during the procedure percent saturation,The difficult in carrying out the bronchoscopic procedure by physician during the procedure Visual analogue scale | — |
Countries
Thailand
Contacts
Public ContactWanvisa Boonfueang
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed