Efficacy and Safety of two artificial saliva base polymers containing with 0.1% pilocarpine for Treatment of xerostomia: A Randomized Clinical Trial

Comparison of the Efficiency of Artificial Saliva with Pilocarpine in Management of Xerostomia

Status

Recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20200902001

Enrollment

Registered

2020-09-02

Start date

2020-09-02

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

xerostomia or dry mouth hyposalivation xerostomia hyposalivation

Interventions

sodium carboxymethyl cellulose in artificial saliva containing with 0.1% pilocarpine,Sodium polyacrylate in artificial saliva containing with 0.1% pilocarpine

Active Comparator Drug,Experimental Drug

sodium carboxymethyl cellulose in artificial saliva,sodium polyacrylate in artificial saliva

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Having questionnaires xerostomia inventory score more than 11

Exclusion criteria

Exclusion criteria: 1.Pathologic oral lesion 2.Alcohol and caffeine consumption 3.Smoking 4.Sodium benzoate allergy 5.Pilocarpine allergy or having any contraindication

Design outcomes

Primary

Measure	Time frame
quanlity and quantity of saliva at 6 weeks Sialometry, saliva pH, buffer capacity of saliva	—

Secondary

Measure	Time frame
safety after used artificial saliva at 6 weeks questionnaires	—

Countries

Thailand

Contacts

Public ContactWilairat Sarideechaigul

Khon Kaen University

anndent17@hotmail.com+66816613325

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026