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Efficacy of sub-mucosal injection of chymotrypsin, oral serratiopeptidase and oral corticosteroids for reduction postoperative complications following impacted lower third molars surgery: a prospective, randomized, double-blinded, controlled clinical trial

Efficacy of sub-mucosal injection of chymotrypsin, oral serratiopeptidase and oral corticosteroids for reduction postoperative complications following impacted lower third molars surgery: a prospective, randomized, double-blinded, controlled clinica

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20200828006
Enrollment
Unknown
Registered
2020-08-28
Start date
2014-08-27
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

1. Adult healthy patients who were American Society of Anesthesiologists (ASA) group I and required surgical extraction of unilateral or bilateral complete impacted mandibular third molars. lower third molar surgery

Interventions

Oral serratiopeptidase group : consisting of 20 patients who received 10 mg oral serratiopeptidase (Cipzen Forte) at immediate post&#45
operative time and twice a day for post&#45
operative five days
,Dexamethasone group: consisting of 20 patients who received 8 mg oral corticosteroids (Dexamethasone) at immediate post&#45
operative five days. ,Chymotrypsin group : consisting of 20 patients who received pre&#45
operative sub&#45
mucosal injection of 5 mg chymotrypsin (Alfa Chymotrypsin) at pterygo&#45
mandibular space following the inferior alveolar nerve block
Experimental Drug,Active Comparator Drug,Experimental Drug
oral serratiopeptidase ,oral corticosteroids ,Chymotrypsin group

Sponsors

Faculty of Dentistry, University of Technology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 39 Years

Inclusion criteria

Inclusion criteria: 1. Adult healthy patients who were American Society of Anesthesiologists (ASA) group I and required surgical extraction of unilateral or bilateral complete impacted mandibular third molars. 2. All subjects had to presented with the same surgical difficulty concerning similar bone impaction and had the same classification in relation to the occlusal surface of the neighboring second molar (Class B: the impacted teeth are partly buried in the bone, or the occlusal plane of the impacted tooth is between the occlusal plane and the neighboring tooth's cervical line).

Exclusion criteria

Exclusion criteria: 1. Patient administered other drugs such as NSAIDS and steroids. 2. Patient has allergy to the drugs used in this study. 3. Pregnant patient or a patient with lactation. 4. Immunocompromized patients with diabetic or hypertension (from patient’s history). 5. Patients with irradiated maxillofacial region. 6. Mentally challenged patients and patients unable to come for follow up visits. 7. patients with acute and subacute pericoronitis

Design outcomes

Primary

MeasureTime frame
pain and facial swlling 2 days, 3 days and 5 days visual analaoque sacle—

Secondary

MeasureTime frame
mouth opening day tape methods in millimeters—

Countries

yemen

Contacts

Public ContactEssam almoraissi

Thamar University

dressamalmoraissi@gmail.com0541469404

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026