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A Randomized Controlled Trial of Efficacy of Split-dosing versus Nonsplit-dosing of Ergocalciferol on Serum 25-hydroxyvitamin D in Chronic Kidney Disease Patients

A Randomized Controlled Trial of Efficacy of Split-dosing versus Nonsplit-dosing of Ergocalciferol on Serum 25-hydroxyvitamin D in Chronic Kidney Disease Patients

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20200820007
Enrollment
Unknown
Registered
2020-08-20
Start date
2019-03-25
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CKD patients at out patient department of Phramongkutklao hospital with vitamin D deficiency or insufficiency [25(OH)D<30 ng/mL]. Ergocalciferol&#44

Interventions

given ergocalciferol 60&#44
000IU
single dose on every Monday day&#44
for 12 weeks. Main outcome measure were serum 25(OH)D concentrations&#44
serum calcium&#44
serum phosphate&#44
and parathyroid level at 12 weeks after enrolled,given ergocalciferol 20&#44
000 IU on every Monday&#44
Friday for 12 weeks. Main outcome measure were serum 25(OH)D concentrations&#44
and parathyroid level at 12 weeks after enrolled
Active Comparator Drug,Active Comparator Drug
Nonsplit dose of ergocalciferol at 60&#44
000 IU ,split dose of ergocalciferol at 60&#44
000 IU

Sponsors

None
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: CKD non dialysis Age>18 years Serum 25(OH)D level 30 ng/mL

Exclusion criteria

Exclusion criteria: primary or tertiary hyperparathyroidism On ergocalciferol On active form of vitamin D Ca> 10.5 mg/dL Phosphate> 5.5 mg/dL Cancer

Design outcomes

Primary

MeasureTime frame
serum 25(OH)D in CKD patient. 12 weeks Level of serum 25(OH)D

Secondary

MeasureTime frame
Safety outcome 8&#44; 12 weeks Serum calcium and phosphate

Countries

Thailand

Contacts

Public ContactNaowanit Nata

Phramongkutklao Hospital and College of Medicine

Naowanitnata2017@gmail.com662-6444676

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026