pre-
Conditions
Interventions
lactulose or daily for 14 days. After a 7-
day washout period,
the patients were switched to the other substance for another 14 days. ,senna and ispaghula husk daily for 14 days. After a 7-
the patients were switched to the other substance for another 14 days.
Active Comparator Drug,Active Comparator Drug
lactulose and,senna and ispaghula
Sponsors
None
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: CKD stage 4 and 5 with non-dialysis, aged > 18 years, who were diagnosed constipation by ROME IV criteria
Exclusion criteria
Exclusion criteria: history of abdominal surgery, gut obstruction, pregnancy, end stage renal disease who on dialysis, history of lactulose, senna, fiber allergy, and history of bulimia and anorexia. Discontinuation criteria included unwillingness to continue study, intolerable side-effects or allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| compare efficacy of lactulose and combination of senna and ispaghula husk for treat constipations in 14 days complete spontaneous bowel movement (CSBM) per week which complete spontaneous was assessed using st | — |
Secondary
| Measure | Time frame |
|---|---|
| change of stool appearance 14 days Bristol stool form scale (BSFS). | — |
Countries
Thailand
Contacts
Public ContactNaowanit Nata
Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine
Outcome results
None listed