Disease remission in lupus nephritis patients between 2 drug regimens Complete remission and time to renal response
Conditions
Interventions
Mycophenolate mofetil 1.5 g/day titrate to 2 g/day plus standard corticosteroid,Multitarget therapy consists of Tacrolimus,
fixed dose Mycophenolate mofetil 1 g/day and standard corticosteroid
Active Comparator Drug,Active Comparator Drug
Standard mycophenolate mofetil,Multitarget therapy
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Biopsy proven lupus nephritis class III/IV/V (new case or relapsed) 2. Pathologic chronicity index (CI) < 4 3. At least 24 hr urine protein 1.5 gm/day in LN class III, V 4. Serum creatinine < 2 mg/dl 5. Patient’s informed consent
Exclusion criteria
Exclusion criteria: 1. Disease progression as rapidly progressive glomerulonephritis 2. History of treatment with Methylprednisolone/ Cyclophosphamide/ Mycophenolate mofetil/ Tacrolimus within 12 weeks before enrollment 3. HBV/ HCV/ HIV co-infection 4. Diabetes Mellitus 5. Pregnancy/ Lactation/ Refused contraception
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete remission 24 weeks Clinical and laboratory assessment | — |
Secondary
| Measure | Time frame |
|---|---|
| Partial remission, overall response rate, time to renal response, safety and adverse effect 24 weeks Clinical and laboratory assessment | — |
Countries
Thailand
Contacts
Public ContactLaddaporn Wongluechai
Renal division, Medicine department, Maharat Nakhon Ratchasima Hospital
Outcome results
None listed