Overweight and obese individuals which has BMI more than 30 kg/m2 up to 29.9 kg/m2. overweight obese
Conditions
Interventions
The participants will recievce supplementation as Irvingia gabonenesis kernel extract.,The participants will recievce placebo which is same size,
color and smell with the treatment group.
Active Comparator Drug,Placebo Comparator Drug
Irvingia gobonensis kernel extract,Placebo group
Sponsors
Blacmores company
Khon Kaen University
Eligibility
Sex/Gender
All
Age
30 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1) Men or women age between 30 and 59 years old 2) BMI range between 23 and 29.9 kg/m2 3) Stable weight (within four kilograms changed) at least three months before the supplementation phase 4) Consistency of regular medicine such as hypertension and dyslipidemia drugs 5) SGPT and creatinine levels less than 35 IU/L and 1 mg/dL respectively 6) No attempt to reduce weight at least three months before the randomization 7) Not taking any supplementation at least three months before the randomization. 8) Non-smoker and alcohol drinker
Exclusion criteria
Exclusion criteria: 1) Pregnancy 2) Diagnosed with type 2 diabetes mellitus (fasting blood glucose > 126 mg/dL) 3) Diagnosed with cardiovascular diseases except hypertension 4) Cannot maintain regular medicines 5) Diagnosed with neuromuscular disease 6) Diagnosed with orthopedic problems and history of bone fracture 7) Diagnosed with liver and kidney diseases 8) Diagnosed with autonomic neuropathy 9) Chronic infections (HIV, TB, Hepatitis) 10) Diagnosed with endocrine diseases, thyroid conditions, polycystic ovary syndrome (PCOS) 11) Had history with drug or natural ingredients allergy which was contained in the tablet
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fat oxidation rate day 91, 175 indirect calorimetry | — |
Secondary
| Measure | Time frame |
|---|---|
| CHO oxidation rate day 91, 175 indirect calorimetry,Adiposity day 91, 112, 133, 175 Dual-energy X-ray absorptiometry (DXA),Resting metabolic rate day 91, 175 indirect calorimetry,Lipid profiles day 1, 91, 112, 133, 175 Refloton Plus, U.S.,Plasma malondialdehyde day 91, 112, 133, 175 Depler method,Plasma vitamin c day 91, 112, 133, 175 Zhang's method,hs-CRP day 91, 112, 133, 175 Cobas,Adiponectin 4 times human adiponectin enzyme immunoassay kit (Cayman, USA),Leptin day 91, 112, 133, 175 human leptin enzyme immunoassay kit (Cayman, USA),Liver and kidney function day 91, 112, 133, 175 Refloton Plus, U.S.,Exercise capacity day 91, 175 ergometer,Telomere length day 91, 175 RT-PCR | — |
Countries
Thailand
Contacts
Public ContactNaruemon Leelayuwat
Department of Physiology, faculty of Medicine, Khon Kaen University (KKU) 123 Moo 16 Mittapap Rd., N
Outcome results
None listed