Beta-
Conditions
Interventions
Patients treated with curcumin extract at the dosage of 1000 mg/day for 24 weeks,Patients treated with curcumin extract at the dosage of 500 mg/day for 24 weeks
Experimental Other,Experimental Other
Curcumin extract 1000 mg/day,Curcumin extract 500 mg/day
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
Agricultural Research Development Agency (Public Organization)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Beta-thalassemia/Hb E (2) Hemoglobin concentration 5-9 g/dl and serum ferritin level >= 600 ng/ml
Exclusion criteria
Exclusion criteria: (1) Lactation or pregnancy (2) Receiving blood transfusion within three months prior to the enrollment (3) Receiving medications for thalassemia apart from folic acid during one month before the enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Iron parameters Baseline, week 24th of intervention Automated chemistry analyzer/ELISA ,Inflammatory parameters Baseline, week 24th of intervention Particle enhanced immunoturbidimetry/Multiplex cytokine assay,Oxidative stress parameters Baseline, week 24th of intervention Thiobarbituric acid assay/Flow cytometry | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver and renal function tests Baseline, week 24th of intervention Automated chemistry analyzer,Hemoglobin concentration Baseline, week 24th of intervention Automated hematology analyzer ,D-dimer Baseline, week 24th of intervention Two-step enzyme immunoassay sandwich method | — |
Countries
Thailand
Contacts
Public ContactRuchaneekorn Kalpravidh
Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
Outcome results
None listed