mild cognitive impairment elderly mild cognitive impairment elderly Thai exercise Ruesi Dadton BDNF irisin oxidative stress mind body medicine
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: - Age between 50-80 year - Ability to read write hearing, speaking and communication in Thai language - Body mass index at low to moderate risk (19 - 27.5 kg/m2) - Complaint cognition more than normal in the same age or compare with the past - MMSE scores less than 24 points - MoCA) scores less than 26 points - Diagnosed from neurologist that amnestic-MCI
Exclusion criteria
Exclusion criteria: - Diagnosed with dementia - History or diagnosis with cardiovascular disease - Neurological disease or mental symptoms - Blood pressure more than 160/100 mmHg - History of alcoholism or drugs addiction - Spine problems such as scoliosis, spine trauma, and disc herniation - Knee pain (VAS at least 8) - Cannot sit in a cross position - Severe accidents in the prior 3 months - History of brain accident or brain injury - Continue regular exercise within the prior 2 years ( 30 min/day or over, 3 days/week or over) - Intent to exercise that related to Ruesi Dadton, Tai Chi, Yoga, or Chi-Qong within three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cognitive functions 12 weeks MoCA, MMSE,cognitive functions 12 weeks MMSE,BDNF 12 weeks blood serum,irisin 12 weeks blood serum,oxidative stress 12 weeks urine ,balance 12 weeks single leg standing,frialty 12 weeks grip strength | — |
Secondary
| Measure | Time frame |
|---|---|
| cognitive function 12 weeks verbal fluency test,cognitive function 12 weeks Trial making part A, B, B-A | — |
Countries
Thailand
Contacts
Ubon Ratchathani Rajabhat University