Diabetic nephropathy with aged over 18 yrs Carnosine, diabetic nephropathy, transforming growth factor beta
Conditions
Interventions
Carnosine 2 g/day,Placebo
Experimental Dietary Supplement,Placebo Comparator No treatment
carnosine,placebo
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: The inclusion criteria were T2DM, age of 18 years old or older, urine albumin-creatinine ratio (UACR) of 30-299 mg/g creatinine at least 2 in 3 within 3 to 6 months, stable dose of ACEI or ARB for blood pressure control at least 3 months before enrolling, and stable hemoglobinA1C (HbA1C) within 3 months prior to the study.
Exclusion criteria
Exclusion criteria: The exclusion criteria were active infections, chronic kidney disease from non-diabetic cause, advanced malignancy, history of hypersensitivity to protein nutrients, problems with nutrients absorption of gastrointestinal tract and liver disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome was the decrease in the level of urinary levels of TGF-β at 12 weeks after start of the intervention solid-phase specific sandwich enzyme-linked immunosorbent assay (ELISA) | — |
Secondary
| Measure | Time frame |
|---|---|
| secondary outcome was the decrease in the level of urine albumin/creatinine ratio at 12 weeks after start of the intervention immunonephelometric assay | — |
Countries
Thailand
Contacts
Public ContactNarongrit Siriwattanasit
Division of Nephrology, Department of Medicine, Phramongkutklao Hospital
Outcome results
None listed