Postmenopausal women presenting with genotourinary syndrome of menopause vaginal microbiota,
Conditions
Interventions
Vaginal estrogen(estriol) plus probiotic
Vaginal estrogen(estriol) plus probiotic 1 tab vaginal suppo before bed time for consecutive 12 days ,
then 1 tab vaginal suppo 2 tabs per week until 12 weeks
Experimental Drug
Sponsors
Ratchadapiseksompoch fund
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Natural postmenopause women (more than 12 months of amenorrheic period without other related organic pathologies) 2. Age 45-75 years 3. Women presenting with at least one clinical symptom of genitourinary syndrome of menopause(vaginal dryness, dyspareunia, itching, irritation)
Exclusion criteria
Exclusion criteria: 1. Receive treatment with vaginal moisturizers, vaginal lubricant, vaginal laser, systemic or local estrogens within 90 days before recruitment 2. Pelvic organ prolapse stage 3 or higher 3. BMI of more than 35 kg/m2 4. Vaginal infection within 30 days 5. Any type of vaginal surgery within 90 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Types and quantities of bacteria before and after estrogen and probiotic treatment 12 weeks Next generation (16sRNA) method | — |
Secondary
| Measure | Time frame |
|---|---|
| Types and quantities of bacteria in postmenopausal women with genitourinary syndrome of menopause 12 weeks Next generation (16sRNA) method | — |
Countries
Thailand
Contacts
Public ContactAmmarin Suwan
Chulalongkorn University
Outcome results
None listed