Increase of salivary Lf and oral Candida
Conditions
Interventions
Compairision of salivary Lf levels and the presence of oral Candida species in oral lichen planus (OLP)patients undergoing general standard treatment with a topical steroid,
fluocinolone acetonide 0.1% in orabase (0.1% FAO) at baseline and 3 months after treatment.
Screening
Sponsors
Faculty of Dentistry, Chulalongkorn University
Research Division,
Faculty of Dentistry,
Chulalongkorn University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Oral lichen planus patients (OLP) with severity evaluated according to Thongprasom scoring system as score 3, 4 or 5. 2. OLP patients have not used a topical steroid before participating in this study. 3. OLP patients are treated with 0.1% FAO applied 3 times daily for 3 months during the investigation. 4. Participants have no signs of oral candidiasis at the beginning of the study. 5. Participants have no history of treatment with chemotherapy or radiotherapy. 6. Participants have no signs of dry mouth. 7. Participants have no history of any disease or medical condition predisposing them to oral candidiasis. 8. Participants have no history of taking antifungal agents, using an antiseptic mouthwash, or smoking for at least 1 month.
Exclusion criteria
Exclusion criteria: 1. Participants use antifungal agents during the investigation time. 2. To change in type or preparation of topical steroid treatment during the investigation time. 3. Participants would like to withdraw from the research project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Salivary lactoferrin at the baseline and 3 months after treatment with topical steroid enzyme-linked immunosorbent assay (ELISA) | — |
Secondary
| Measure | Time frame |
|---|---|
| Oral Candida species at the baseline and 3 months after treatment with topical steroid Salivary culture | — |
Countries
Thailand
Contacts
Public ContactChanwit Prapinjumrune
Unaffiliated
Outcome results
None listed