Effect of Thai berry- derived healthy edible film mixed with Morus alba leaf extract on cognitive processing in 12-18 years old children

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20200716003

Enrollment

Registered

2020-07-16

Start date

2021-04-22

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy conditions Mulberry leaf Thai berry Edible film Brain supplement Cognitive process Working memory Children

Interventions

Subjects are received the placebo product which has same color and smell look like edible film mixed with Mulberry leaf extract ,Subjects are received edible film mixed with Mulberry leaf extract 10 g

Placebo Comparator Dietary Supplement,Experimental Dietary Supplement,Experimental Dietary Supplement

Placebo,Edible film mixed with Mulberry leaf extract 10 gram/day,Edible film mixed with Mulberry leaf extract 20 gram/day

Eligibility

Sex/Gender

All

Age

12 Years to 18 Years

Inclusion criteria

Inclusion criteria: 1.Aged between 12-18 years old 2.Body Mass Index (BMI) between 18.5-25 kg/m2 3.MOCA test>25 4.Exercise less than 3 times/week

Exclusion criteria

Exclusion criteria: 1.Attention deficit, autistic, dyslexia, cardiovascular diseases, respiratory diseases, neuropsychological diseases, head injury, Gout, diabetes mellitus, liver disease, cancer,autoimmune disease and hematological disorder 2.Volunteers who require supplements or any drug that effect on the nervous system by order of the doctor during trial 3.Volunteers who don't follow instructions during the trial 4.Smoking more than 10 pieces/day 5.Alcohol addiction 6.Volunteers who participate in other projects.

Design outcomes

Primary

Measure	Time frame
N100 and P300 8 weeks Event related evoked potentials (ERPs)	—

Secondary

Measure	Time frame
Working memory test 8 weeks Computer,Salivary cortisol 8 weeks Elisa method,Acetylcholinesterase enzyme activity 8 weeks Elisa method,Monoamine oxidase enzyme include Monoamine oxidse typeA and Monoamine oxidase typeB 8 weeks Elisa method,brain-derived neurotropic factor (BDNF), GABA transaminase (GABA-T) and glutamate decarboxylase (GAD 8 weeks Elisa method,Inflammatory markers include C-Reactive protein (CRP), IL-1Î², IL-6, and TNF-Î± 8 weeks Elisa method,Oxidative stress markers include 8-hydroxy-2'-deoxyguanosine (8-OHdG) and DNA methylation 8 weeks Elisa method,The changes of MDA, SOD, GSH-Px and CAT 8 weeks Elisa method,Stool examination include total lactic acid, bifidobacterial and short chain fatty acid 8 weeks laboratory,Psychological symptom using SCL-90 questionnaire 8 weeks Questionnaire,Physical activity and Dietary questionnaire 8 weeks Questionnaire,Electrocardiogram 8 weeks electrocardiography equipment	—

Measure

Time frame

Working memory test 8 weeks Computer,Salivary cortisol 8 weeks Elisa method,Acetylcholinesterase enzyme activity 8 weeks Elisa method,Monoamine oxidase enzyme include Monoamine oxidse typeA and Monoamine oxidase typeB 8 weeks Elisa method,brain-derived neurotropic factor (BDNF), GABA transaminase (GABA-T) and glutamate decarboxylase (GAD 8 weeks Elisa method,Inflammatory markers include C-Reactive protein (CRP), IL-1Î², IL-6, and TNF-Î± 8 weeks Elisa method,Oxidative stress markers include 8-hydroxy-2'-deoxyguanosine (8-OHdG) and DNA methylation 8 weeks Elisa method,The changes of MDA, SOD, GSH-Px and CAT 8 weeks Elisa method,Stool examination include total lactic acid, bifidobacterial and short chain fatty acid 8 weeks laboratory,Psychological symptom using SCL-90 questionnaire 8 weeks Questionnaire,Physical activity and Dietary questionnaire 8 weeks Questionnaire,Electrocardiogram 8 weeks electrocardiography equipment

—

Countries

Thailand

Contacts

Public ContactJintanaporn Wattanathorn

Khon Kaen University

jinwat@kku.ac.th6618721809

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026