Pediatric septic shock Septic shock Hydrocortisone Children
Conditions
Interventions
Continuous infusion hydrocortisone in the dose of 100 mg/m2/day continuous drip in 24 hr until shock reversal with a maximum of 7 days.,Intermittent bolus hydrocortisone in the dose of 25 mg/m2/day q
Active Comparator Drug,Active Comparator Drug
Continuous infusion hydrocortisone ,Intermittent bolus hydrocortisone
Sponsors
none
Eligibility
Sex/Gender
All
Age
1 Months to 18 Years
Inclusion criteria
Inclusion criteria: Children 1 month to 18 year of age admitted to PICU with catecholamine-dependent septic shock who are at risk for adrenal insufficiency as followings and received loading dose of hydrocortisone; Risk for adrenal insufficiency: - Physical signs e.g. purpura fulminans or diagnosed of Waterhouse-Friderichsen syndrome - History of hypothalamic-pituitary-adrenal axis abnormalities e.g. congenital adrenal hyperplasia, pituitary gland disease - History of corticosteroid use either long term (longer than 2 weeks within last 6 months) or short term (not longer than 2 weeks within last 4 month - History of etomidate use - History of antifungals use within last 7 days
Exclusion criteria
Exclusion criteria: Hypersensitivity of hydrocortisone Do-not-resuscitate patients Post cardiac arrest Patient receiving treatment with antifungals for systemic fungal infections at time of randomization
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Shock reversal At the time of shock reversal Time to shock reversal from diagnosis of septic shock | — |
Secondary
| Measure | Time frame |
|---|---|
| Vasoactive-inotropic drug use At day 28 after diagnosis of septic shock Vasoactive-inotropic drug-free days to day 28 | — |
Countries
Thailand
Contacts
Public ContactNutnicha Preeprem
Siriraj Hospital, Mahidol University
Outcome results
None listed