In vivo Confocal Microscopic Analysis of Corneal Nerve And Inflammatory Cells in Patient with Keratoconus

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20200715005

Enrollment

Registered

2020-07-15

Start date

2020-07-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Study the corneal nerve characteristics and inflammatory cells in patient with Keratoconus. In vivo Confocal Microscopic, Corneal Nerve, Keratoconus

Interventions

healthy volunteers,patients with Keratoconus

Prevention,Prevention

normal,KCN

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Thai men or women, healthy, aged 20-50 years 2. Not having a history of eye diseases. Including corneal surgery or previous corneal intervention that may affect the corneal nerves, including corneal inflammation, such as corneal ulcer, Herpes zoster infection, corneal injury, dry eye, glaucoma eye drops or undergoing glaucoma surgery, corneal dystrophy, bullous keratopathy, etc. 3. There are no physical diseases affecting the nerves throughout the body, including nerves that raise the cornea, such as diabetic mellitus, stroke and systemic neuropathy. 4. No diseases that cause inflammation throughout the body, including the eye (systemic inflammatory disease) such as autoimmune disease or septicemia. 5. Normal corneal sensation. Which was confirmed using a Cochet Bonnet esthesiometer.

Exclusion criteria

Exclusion criteria: 1. Preliminary eye examination results found abnormalities of the cornea by a slit lamp biomicroscope including: Corneal abnormalities or abnormal cornea examination, Irregular eyes or blinking eyes, Irregular ocular surface, Irregular photoreceptor response, abnormal cornea sensitivity. 2. Blood glucose test results found to be diabetic or tend to have diabetes (impair glucose tolerance test) 3. Anaesthetic allergy

Design outcomes

Primary

Measure	Time frame
Inflammatory cells and corneal nerve density Visit 0 HRT-III confocal microscopy	—

Secondary

Measure	Time frame
Corneal nerve differentiation Visit 0 Compare corneal nerve density in between groups	—

Countries

Thailand

Contacts

Public ContactChareenun Chirapapaisan

Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University

chareenun@gmail.com024198037

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026