A Comparison of Fentanyl and Esmolol on Attenuation of Hemodynamic Response to Tracheal Intubation in Hypertensive Patients

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20200708003

Enrollment

Unknown

Registered

2020-07-08

Start date

2018-12-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension and tachycardia after intubation hypertension&#44

Interventions

drug was given 3 minutes before intubation,drug was given 5 minutes before intubation

Experimental Drug,Active Comparator Drug

esmolol 1.5 mg/kg,Fentanyl 2 mcg/kg

Eligibility

Sex/Gender

All

Age

35 Years to 65 Years

Inclusion criteria

Inclusion criteria: ASA I-II Underlying hypertension BMI <30 Scheduled for elective surgery and require oral intubation

Exclusion criteria

Exclusion criteria: History of cardiac disease Asthma/reactive airway disease Baseline heart rate < 60 Anticipated difficult airway Pregnancy On beta-blocker

Design outcomes

Primary

Measure	Time frame
hemodynamic response after intubation immediate after intubation, 3 , 5 and 10 minutes after intubation noninvasive blood pressure measurement and heart rate monitor	—

Secondary

Measure	Time frame
Bradycardia and hypotension after intubation Heart rate and blood pressure from anesthetic monitor	—

Countries

Thailand

Contacts

Public ContactThanyalak Thamjamrassri

Department of Anesthesiolgy

thanyalak.tha@mahidol.edu6681 956 2004

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026